LymphedemaV1, Main, Exploration, bibRecord, 003090

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42*

Identifieur interne : 003090 ( Main/Exploration ); précédent : 003089; suivant : 003091

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42*

Auteurs : Nadejda Valtcheva [Suisse] ; Adriana Primorac [Suisse] ; Giorgia Jurisic [Suisse] ; Maija Hollmén [Suisse] ; Michael Detmar [Suisse]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3861625

Abstract

Background: The identification of G protein-coupled receptors (GPCRs) specific for the lymphatic endothelial cells (LECs) is essential for establishing drugs targeting the lymphatic system.

Results: GPR97 is an orphan adhesion GPCR that regulates LEC migration.

Conclusion: GPR97 is the first known adhesion GPCR involved in lymphatic remodeling.

Significance: This first evidence that adhesion GPCRs govern LEC motility opens new possibilities for modulating lymphangiogenesis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861625

DOI: 10.1074/jbc.M113.512954
PubMed: 24178298
PubMed Central: 3861625

Affiliations:

Suisse

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42<xref ref-type="fn" rid="FN1">*</xref>
</title>
<author><name sortKey="Valtcheva, Nadejda" sort="Valtcheva, Nadejda" uniqKey="Valtcheva N" first="Nadejda" last="Valtcheva">Nadejda Valtcheva</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Primorac, Adriana" sort="Primorac, Adriana" uniqKey="Primorac A" first="Adriana" last="Primorac">Adriana Primorac</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hollmen, Maija" sort="Hollmen, Maija" uniqKey="Hollmen M" first="Maija" last="Hollmén">Maija Hollmén</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24178298</idno>
<idno type="pmc">3861625</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861625</idno>
<idno type="RBID">PMC:3861625</idno>
<idno type="doi">10.1074/jbc.M113.512954</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002E93</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E93</idno>
<idno type="wicri:Area/Pmc/Curation">002E92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002E92</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001F25</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F25</idno>
<idno type="wicri:Area/Ncbi/Merge">005E85</idno>
<idno type="wicri:Area/Ncbi/Curation">005E85</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005E85</idno>
<idno type="wicri:doubleKey">0021-9258:2013:Valtcheva N:the:orphan:adhesion</idno>
<idno type="wicri:Area/Main/Merge">003095</idno>
<idno type="wicri:Area/Main/Curation">003090</idno>
<idno type="wicri:Area/Main/Exploration">003090</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42<xref ref-type="fn" rid="FN1">*</xref>
</title>
<author><name sortKey="Valtcheva, Nadejda" sort="Valtcheva, Nadejda" uniqKey="Valtcheva N" first="Nadejda" last="Valtcheva">Nadejda Valtcheva</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Primorac, Adriana" sort="Primorac, Adriana" uniqKey="Primorac A" first="Adriana" last="Primorac">Adriana Primorac</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hollmen, Maija" sort="Hollmen, Maija" uniqKey="Hollmen M" first="Maija" last="Hollmén">Maija Hollmén</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich</wicri:regionArea>
<wicri:noRegion>8093 Zurich</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The identification of G protein-coupled receptors (GPCRs) specific for the lymphatic endothelial cells (LECs) is essential for establishing drugs targeting the lymphatic system.</p>
<p><bold>Results:</bold>
 GPR97 is an orphan adhesion GPCR that regulates LEC migration.</p>
<p><bold>Conclusion:</bold>
 GPR97 is the first known adhesion GPCR involved in lymphatic remodeling.</p>
<p><bold>Significance:</bold>
 This first evidence that adhesion GPCRs govern LEC motility opens new possibilities for modulating lymphangiogenesis.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Suisse</li>
</country>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Valtcheva, Nadejda" sort="Valtcheva, Nadejda" uniqKey="Valtcheva N" first="Nadejda" last="Valtcheva">Nadejda Valtcheva</name>
</noRegion>
<name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<name sortKey="Hollmen, Maija" sort="Hollmen, Maija" uniqKey="Hollmen M" first="Maija" last="Hollmén">Maija Hollmén</name>
<name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name>
<name sortKey="Primorac, Adriana" sort="Primorac, Adriana" uniqKey="Primorac A" first="Adriana" last="Primorac">Adriana Primorac</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003090 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003090 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3861625
   |texte=   The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42*
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24178298" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42*

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42*

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.